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Pica Behavior
Visceral illness is an undesirable side effect of some pharmaceutical treatments and experimental paradigms, and confounds the study of appetite regulation. By definition, visceral illness describes a range of nausea and concomitant anorexia caused by many factors, including
ingestion of toxins, infections, presence of cancer, etc.
Consumption of non-nutritive substances (pica behavior) such
as kaolin, has been documented to reflect feelings of visceral
illness in rats and mice. Cost Effective Indicator
Research Diets offers, a non-nutritive kaolin pellet for use in your research. It is a cost effective, easy to use, early indicator of visceral illness in your experimental animals. Early identification of this adverse experience profile of a compound saves money and streamlines the rational drug design process. Researchers studying metabolic disorders rely on food intake measures as a primary endpoint in evaluating the efficacy of experimental treatments. However, anorectic effects can reflect primary efficacy or secondary effects due to visceral illness. Consumption of kaolin offers early insight into the mechanisms operating in your in vivo studies.
Contact one of our nutrition scientists for more information. |
